Citrullus colocynthis is a traditionally used medicinal plant claimed to possess antioxidant, antidiabetic and anti-inflammatory activity. The present study was conducted with the purpose to evaluate the invitro antioxidant activity in leaves and stem of Citrullus colocynthis. The enzymatic antioxidants such as catalase, super oxide dismutase, glutathaione reductase, glutathaione reductase and glutathiaone-S- transferase and non enzymic antioxidant (ascorbic acid, ά- tocoperol, reduced glutathiaone, total carotenoids and flavonoids) were found to be present. The free radicals scavenging (DPPH, Hydroxyl radical, and Nitric oxide) activity also observed. The result obtained in the present study indicated that the Citrullus colocynthis might be a good source of natural antioxidant.
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